Repolarization gradients and arrhythmogenicity in the murine heart
نویسندگان
چکیده
منابع مشابه
Is there a significant transmural gradient in repolarization time in the intact heart?: Repolarization Gradients in the Intact Heart.
In 1880, Burdon-Sanderson and Page recorded the ECG of the frog simultaneously with monophasic action potentials from the base and the apex of the left ventricle (LV).1 Part of the ventricular muscle was injured with a hot wire, and monophasic action potentials were recorded as the potential difference between the injured region and an uninjured area. The ECG was recorded with a capillary elect...
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INTRODUCTION Brugada syndrome (BrS) is associated with loss of Na(+) channel function and increased risks of a ventricular tachycardia exacerbated by flecainide but reduced by quinidine. Previous studies in nongenetic models have implicated both altered conduction times and repolarization gradients in this arrhythmogenicity. We compared activation latencies and spatial differences in action pot...
متن کاملTransmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3.
BACKGROUND Congenital and acquired long QT syndrome (LQTS) are caused by abnormalities of ionic currents underlying ventricular repolarization. For a better understanding of the mechanisms by which functional electrical instability at the level of the whole heart leads to torsade de pointes (TdP), a novel model of LQT3 was developed and the role of transmural dispersion of repolarization for th...
متن کاملHeart repolarization changes after anthracycline therapy in the children with cancer
Background Anthracyclines are important components of many chemotherapeutic protocols. The present study aimed to evaluate the repolarization changes in electrocardiography (ECG) which may predict drug induced arrhythmia. Materials and Methods In this cross-sectional study, the recorded ECGs were assessed for QT dispersion (QTd), QT corrected dispersion (QTcd), T peak to Tend dispersion (TPe...
متن کاملCorrelation of repolarization of ventricular monophasic action potential with ECG in the murine heart.
Transgenic mice have become important experimental models in the investigation of mechanisms causing cardiac arrhythmias because of the ability to create strains with alterations in repolarizing membrane currents. It is important to relate alterations in membrane currents in cells to their phenotypic expression on the electrocardiogram (ECG). The murine ECG, however, has unusual characteristics...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2007
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2007.140269